Q1.
How do cells monitor their growth to maintain a balance?
Answer
By balancing the making of new cells against the deliberate, controlled death of old ones. The main mechanism is Programmed Cell Death (PCD).
- PCD is a genetically regulated and organised process of selective cell destruction — the cell dismantles itself neatly on instruction, instead of bursting and damaging its neighbours.
- It is essential for three things: normal development, cellular quality control, and immune function.
- Contact inhibition works alongside it: in many animal cells, division stops when a cell comes into contact with its neighbours, so a tissue stops growing once it is complete.
- Every cell also has a definite life span. Mature red blood cells, for example, survive about 120 days and are then replaced.
rate of cell division = rate of cell death → tissue size stays constant
division > death → tumour
division < death → tissue wastes away
division > death → tumour
division < death → tissue wastes away
Why it happens: the striking example in the book is the human hand. As an embryo develops, PCD removes the cells between the developing digits, and that is how separate fingers are carved out of a paddle-shaped bud — without it we would have webbed hands. So cell death here is not damage at all; it is a sculptor's tool. The same process removes cells that have picked up faulty DNA before they can become cancerous, which is why PCD counts as quality control. Problems arise at both extremes: if cells do not die when they should, tumours form; if they die too early, tissues break down.